POSTPONED
Tau structure: from cryo-EM to imaging
13:30-13:50 Michel Goedert (LMB-MRC, Cambridge) Structures of aggregated tau conformers
13:50-14:10 Eckhard Mandelkow (DZNE, Bonn) Structural constraints on models of transcellular propagation of tauopathy
14:10-14:30 Susanne Wegmann (DZNE Berlin) The role and (mesoscale) interactions of tau phases in biology
14:30-14:50 Eva-Maria Mandelkow (DZNE, Bonn) Monitoring tau-transgenic mice treated with adenosine A1 inhibitors by PET imaging
14:50-15:05 Naruhiko Sahara (NIRS Chiba Japan) A diagnostic platform of tauopathy using multimodal imaging techniques in human and mouse
15:05-15:20 Bernard Hanseeuw (Louvain, Belgium) [18F]-MK6240 PET to image tau aggregates in AD and other tauopathies
15:20-15:35 Tiago Gil Oliveira (Braga, Portugal) MRI brain atrophy assessment in PART
15:35-16:20 Coffee break and poster
Tau structure: from aggregated species to therapy
16:20-16:40 Louise Serpell (Univ. Sussex, UK) Tau assembly as a rational target for therapy
16:40-17:00 Leonard Petrucelli (Mayo Clinic, FL, USA) Title to come
17:00-17:20 Gail Johnson (Univ. Rochester, NY, USA) BAG3 regulates endocytosis and tau clearance
17:20-17:40 Ronald Melki (CNRS, Fontenay aux Roses) De novo assembled and patients-derived tau strains differential binding to neurons
17:40-17:55 Wiep Scheper (Amsterdam, NL) Granulo-vacuolar degeneration bodies: active lysosomal structures induced by tau pathology
17:55-18:30 Flash talks (5x5 min)
April 27, 2020
8:30 Welcome coffee – Poster setup
9:00 Introduction : Luc Buee and Patrick Brannelly (Rainwater Prize)
Microtubule and non-microtubule tau functions in health & disease
9:25-9:45 Marie C Galas (Univ. Lille, France) Tau oligomers, mitochondria homeostasis & DNA repair
9:45-10:00 Selected from abstract
10:00-10:20 Roland Brandt (Osnabrück Germany) Evolution & regulation of of tau interactions in health & disease
10:20-10:40 Johannes Attems (Newcastle, UK) Tau in ageing/ AD/ PART and FTLD
10:40-10:55 Illana Gozes (Tel Aviv, Israel) Discovery of autism/intellectual disability and cytoskeletal somatic mutations in Alzheimer's brains: the central role of microtubules and tau.
10:55-11:10 Flaviano Giorgini (Univ Leicester, UK) Tau and DJ-1 interactions in health and disease
11:10-11:25 Kevin Richetin (CHUV, Lausanne) Tau accumulation in astrocytes of the DG induces neuronal dysfunction & memory deficits in AD
11:25-11:40 Mathieu Bourdenx (AECOM, NY) Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
11:40-11:55 Pascale Barbier (Univ Aix Marseille) TauR2 and R3 repeats binding on a-tubulin & ß-tubulin respectively, revealed by disulfide exchange
11:55-12:10 Rierola M (Univ. Osnabrück Germany) Are tau isoforms specifically modulating neuronal connectivity and transport dynamics?
12:10-12:25 Ruiqing Ni (ETH Zürich, Switz) Trans-cranial detection of tauopathy in vivo in P301L mice with high-resolution large-fied multifocal illumination fluorescence microscopy
12:25-13:30 Lunch and poster session
"Cras elementum ultrices diam."
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Alzheimer & Tauopathies - Luc Buée
Copyright 2020