Here a few links to follow our different projects funded by ANR and other agencies/associations/charities (former and ongoing)
MAPT alternative splicing
MAPT epigenetics: GWAS in AD: focus on microRNAs
Acetyl transferases in AD (in collaboration)
Nuclear tau functions (to MCG)
Tau degradation (LECMA to MH)
Adenosine receptor A2A  (ADONTAGE - ADORATAU) and caffeine (LECMA) in AD (to DB)
Tau spreading and prion-like propagation: SPREADTAU; the role of TNTs (see video below)
Drug discovery: VCP modulators and also AlzProtecT a spin-off of the lab
 
NOS SPIN-OFFs: AlzProtecT & 4BioDx
Caffeine & A2AR
Actions towards Patient associations and Publics / Actions vers le Grand Public et les associations de malades
 
Flandres maritime Alzheimer May 2015
 
Conférence Santé en Questions, Paris
 
Fondation Cœur & Artères
 
Maladie d'Alzheimer et Tauopathies
 
Conférence semaine bleue 2015 Templemars
Tau pathology is a common feature to many neurological disorders, including Alzheimer’s disease and myotonic dystrophy, altogether merged as Tauopathies. Our laboratory has focussed its primary goals for deciphering etiopathogenesis in these disorders by using human biological samples analyses and developing experimental models. Our project will aim to study Tau biology to understand pathology by analyzing: 1) Regulation of MAPT (tau gene) from an epigenetics, transcriptional and post-transcriptional aspects; 2) Posttranslational modifications of tau, changes in Tau function and pathological consequences; 3) Gene and environmental factors modulating Tau pathology (posttranslational modifications, aggregation and spreading...). Altogether, these analyses will have some consequences on diagnosis and therapeutics..
Our project is supported by LabEx DISTALZ
Activities
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Alzheimer & Tauopathies - Luc Buée
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