European scientists involved in Tau research were in Lille to exchange new ideas and hypotheses on physiological and pathological roles of tau proteins.
April 27, 2017
9:30 Welcome address (Luc Buée and Univ. Lille representatives)
9:45 Introduction: why a European Tau consortium? (J Avila, L Buée, M Medina)
10:00-12:00 Session 1 (Chairs: Irina Alafuzoff & Eckhard Mandelkow)
10:00-10:15 Irina Alafuzoff, Sweden: Tau pathology (incidence and distribution) in humans in various ages and clinical conditions
10:15-10:30 Johannes Attems, UK: The role of tau in the multi-morbid old brain
10:30-10:45 Alberto Rabano, Spain: Tau immunoreactive nuclear indentations in the entorhinal cortex of early Alzheimer's pathology
10:45-11:00 Michel Goedert, UK: The atomic structures of Tau filaments from Alzheimer's disease brain
11:00-11:15 Günter Höglinger, Germany: PSP and CBD: human tauopathy model diseases
11:15-11:30 Anne Rovelet-Lecrux, France: MAPT locus and microduplication
11:30-11:45 Eckhard Mandelkow, Germany: Structural aspects of Tau
11:45-12:00 Isabelle Landrieu, France: Characterization of Tau interactions using NMR spectroscopy
12:00-13:30 Lunch and Poster session
13:30-15:30 Session 2 (Chairs: Anne Rovelet-Lecrux & Jesus Avila)
13:30-13:45 Jesus Avila, Spain: Influence of tau levels and phosphorylation in cognition
13:45-14:00 Malika Hamdane, France: Amino-truncated Tau species
14:00-14:15 Laura Sayas, Spain: Interplay between tau and End binding proteins in neuronal cells
14:15-14:30 Marie Galas, France: Nuclear Tau regulates the structure of neuronal pericentromeric heterochromatin
14:30-14:45 Efthimios Skoulakis, Greece: Tau as a metalloprotein
14:45-15:00 David Blum, France: Tau: a new regulator of brain insulin signaling
15:00-15:15 Thibaud Lebouvier, France: Clinical aspects of Tauopathies
15:15-15:30 Maria Grazia Spillantini, UK: Neurons and glia interaction in tauopathies
15:30-16:00 Coffee break
16:00-18:00 Session 3 (Chairs: Amrit Mudher & Bart Dermaut)
16:00-16:15 Bart Dermaut, France: A developmental role for Tau in adult-onset neurodegenerative disease?
16:15-16:30 Amrit Mudher, UK: One protein, 6 isoforms, numerous functions: isoform-specific tau-toxicity
16:30-16:45 Miguel Medina, Spain: Tau secretion and toxicity
16:45-17:00 Morvane Colin, France: Tau intercellular transfer: from TNTs to extracellular vesicles
17:00-17:15 Eva Maria Mandelkow, Germany: Animal models of Tauopathy
17:15-17:30 Jean-Pierre Brion, Belgium: Tau pathology propagation in in vivo models induced by native human Alzheimer PHF
17:30-17:45 Diane Hanger, UK: Tauopathy and cognitive dysfunction induced by minimal expression of a disease-related fragment of wild-type human tau in Tau35 mice
17:45-18:00 Amy Pooler, Switzerland: Human tau propagation in the absence of mouse tau
April 28, 2017
8:30-10:30 Session 4 (Chairs: Selina Wray & Ioannis Sotiropoulos)
8:30-8:45 Melita Salkovic, Croatia: Pathology of tau protein in a non-transgenic rat model of sporadic Alzheimer's disease
8:45-9:00 Ioannis Sotiropoulos, Portugal: role of Tau on stress-related brain pathologies
9:00-9:15 Illana Gozes, Israel: ADNP: indirect interactions with tau determine cellular faith
9:15-9:30 Wiep Scheper, The Netherlands: UPR and tau pathology
9:30-9:45 Kina Höglund, Sweden: Overview of tau biomarkers in CSF among neurodegenerative disorders
9:45-10:00 Selina Wray, UK: Human stem cell derived neurons as models of tauopathy
10:00-10:15 Norbert Zilka, Tomas Smolek, Michal Novak, Slovakia: The driver and the others: Monitoring of human AD tau spreading in vivo
10:15-10:30 Dirk Beher, Switzerland: O-GlcNAcase inhibitors for tauopathies – translation of a research finding to a clinical candidate molecule
10:30-11:00 Coffee break
11:00-11:45 Round tables
11:45-12:30 Round tables conclusions
12:30-14:00 Lunch & Poster session
14:00-14:30 Funding Opportunities (Chair: Luc Buée)
14:00-14:15 Rosa Sancho, ARUK, UK: Funding opportunities
14:15-14:30 Maï Panchal, LECMA, France: Presentation of LECMA-Vaincre Alzheimer and its European network of non-profit organizations
14:30-15:00 Flash-talks of selected posters (Chairs: W Scheper, J Attems, S Halliez)
14:30-14:35 Rojo A, Spain: Pharmacological targeting of GSK3 and NRF2 provides neuroprotection in a preclinical model of Tauopathy
14:35-14:40 Pickett E, Human tau is sufficient to drive memory deficits in a new AD mouse model
14:40-14:45 Kundel F, Tau-Hsp70 interaction on the single molecule level
14:45-14:50 Alavi Naini SM, Heparan sulfate is critical for tau hyperphosphorylation and tau-associated neuropathology as revealed by a zebrafish model of Tauopathy
14:50-15:50 Quinn JP, Proteolytic cleavage of tau by granzyme A in dementia pathogenesis
15:00-15:15 Awards:
Congratulations to Eleanor Pickett (UK): Awardee for the best flashtalk (Fondation Plan Alzheimer Award)
Congratulations to Maryam Alavi Naini (France), Simon Dujardin (USA) and Sébastien Hébert (Canada), awardees for the best poster communications (BioMedCentrai, DN2M, LiCEND awards)
15:15-16:00 Informal discussion
16:00 Closing of the meeting
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Alzheimer & Tauopathies - Luc Buée
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