L'équipe "Alzheimer et Tauopathies" appartient au Centre de Recherche Lille Neuroscience & Cognition (Inserm U1172) localisé sur le site du CHU de Lille, France. Elle est constituée de 4 chercheurs Inserm/CNRS, 6 enseignants-chercheurs et 6 chercheurs hospitalo-universitaires. Nous nous intéressons aux mécanismes physiopathologiques de la maladie d'Alzheimer et de pathologies apparentées appelées Tauopathies.
L'équipe aborde ces problématiques en analysant le cerveau humain normal et pathologique. Nous développons également des modèles expérimentaux des Tauopathies afin d'identifier de potentielles cibles diagnostiques et thérapeutiques.
Qui sommes-nous ?
“Alzheimer & Tauopathies” team is interested in molecular and pathophysiological mechanisms. Our main contribution has been on the characterization of neuro-degenerative disorders with dysfunction in tau metabolism (expression, splicing, etc…) and the development of experimental models. We also demonstrated that Tau proteins are biomarkers of these disorders and correlated to neuronal death.
Our current research should lead to new diagnostic and therapeutic strategies of Alzheimer’s disease and related disorders. To the level of the etiopathogenesis of Alzheimer’s disease, the understanding of the relationships between amyloid pathology and tau pathology is our main goal. Any molecular actors potentially involved in one of these pathways are evaluated in our experimental “humanized” models, as well as the related pharmacological aspects.
“Alzheimer & Tauopathies” team belongs to the “Lille Neuroscience & Cognition" Research Centre dedicated to Neuroscience investigations and located in Lille, France. http://lilncog.eu/equipe-alzheimer-et-tauopathies/
Our team is interested in pathophysiological mechanisms leading to DEMENTIA and is composed of 16 permanent researchers: full time research scientists, professors and associate professors and clinicians. We also welcome postdoctoral fellows and MSc/PhD students. Our work focuses on the physiopathology of Alzheimer’s disease and related disorders referred to as Tauopathies going from the gene to the clinic and from basic research to biomedical application.
Who we are?
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Alzheimer & Tauopathies - Luc Buée
Copyright 2020